6E2J
Crystal structure of the heterocomplex between human keratin 1 coil 1B containing S233L mutation and wild-type human keratin 10 coil 1B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Keratin, type II cytoskeletal 1 | polymer | 107 | 12790.3 | 1 | UniProt (P04264) Pfam (PF00038) | Homo sapiens (Human) | 67 kDa cytokeratin,Cytokeratin-1,CK-1,Hair alpha protein,Keratin-1,K1,Type-II keratin Kb1 |
| 2 | B (B) | Keratin, type I cytoskeletal 10 | polymer | 104 | 12121.5 | 1 | UniProt (P13645) Pfam (PF00038) | Homo sapiens (Human) | Cytokeratin-10,CK-10,Keratin-10,K10 |
| 3 | C, D, E, F (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 60 | Chemie (HOH) |
Sequence modifications
A: 226 - 331 (UniProt: P04264)
B: 195 - 296 (UniProt: P13645)
| PDB | External Database | Details |
|---|---|---|
| Met 225 | - | initiating methionine |
| Leu 233 | Ser 233 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 193 | - | expression tag |
| Ser 194 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24911.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 384.3 | |
| All* | Total formula weight | 25296.1 |
