6E1A

Menin bound to M-89

6E1A の概要

• エントリーDOI: 10.2210/pdb6e1a/pdb
• 分子名称: Menin, (1S,2R)-2-[(4S)-2-methyl-4-{1-[(1-{4-[(pyridin-4-yl)sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}-1,2,3,4-tetrahydroisoquinolin-4-yl]cyclopentyl methylcarbamate, praseodymium triacetate, ... (4 entities in total)
• 機能のキーワード: inhibitor, protein binding, transcription
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 63309.30

構造登録者

Stuckey, J.A. (登録日: 2018-07-09, 公開日: 2019-07-10, 最終更新日: 2023-10-11)

• 主引用文献: Aguilar, A.,Zheng, K.,Xu, T.,Xu, S.,Huang, L.,Fernandez-Salas, E.,Liu, L.,Bernard, D.,Harvey, K.P.,Foster, C.,McEachern, D.,Stuckey, J.,Chinnaswamy, K.,Delproposto, J.,Kampf, J.W.,Wang, S.; Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.; J.Med.Chem., 62:6015-6034, 2019; PubMed: 31244110; DOI: 10.1021/acs.jmedchem.9b00021

実験手法

X-RAY DIFFRACTION (3.1 Å)