6E13

Pseudomonas putida PqqB with a non-physiological zinc at the active site binds the substrate mimic, 5-cysteinyl-3,4-dihydroxyphenylalanine (5-Cys-DOPA), non-specifically but supports the proposed function of the enzyme in pyrroloquinoline quinone biosynthesis.

6E13 の概要

分子名称Coenzyme PQQ synthesis protein B, ZINC ION, CHLORIDE ION, ... (5 entities in total)
機能のキーワードiron-dependent, hydroxylase, metallo beta-lactamase, oxidoreductase
由来する生物種Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
ポリマー鎖数1
分子量合計34482.14
構造登録者
Evans III, R.L.,Wilmot, C.M. (登録日: 2018-07-09, 公開日: 2019-05-22)
主引用文献
Koehn, E.M.,Latham, J.A.,Armand, T.,Evans 3rd, R.L.,Tu, X.,Wilmot, C.M.,Iavarone, A.T.,Klinman, J.P.
Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway.
J.Am.Chem.Soc., 141:4398-4405, 2019
PubMed: 30811189 (主引用文献が同じPDBエントリー)
DOI: 10.1021/jacs.8b13453
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.349 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2365 0.3% 0.8% 2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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