6E13

Pseudomonas putida PqqB with a non-physiological zinc at the active site binds the substrate mimic, 5-cysteinyl-3,4-dihydroxyphenylalanine (5-Cys-DOPA), non-specifically but supports the proposed function of the enzyme in pyrroloquinoline quinone biosynthesis.

6E13 の概要

• エントリーDOI: 10.2210/pdb6e13/pdb
• 分子名称: Coenzyme PQQ synthesis protein B, ZINC ION, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: iron-dependent, hydroxylase, metallo beta-lactamase, oxidoreductase
• 由来する生物種: Pseudomonas putida (strain ATCC 47054 / DSM 6125 / NCIMB 11950 / KT2440)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34482.14

構造登録者

Evans III, R.L.,Wilmot, C.M. (登録日: 2018-07-09, 公開日: 2019-05-22, 最終更新日: 2024-03-13)

• 主引用文献: Koehn, E.M.,Latham, J.A.,Armand, T.,Evans 3rd, R.L.,Tu, X.,Wilmot, C.M.,Iavarone, A.T.,Klinman, J.P.; Discovery of Hydroxylase Activity for PqqB Provides a Missing Link in the Pyrroloquinoline Quinone Biosynthetic Pathway.; J.Am.Chem.Soc., 141:4398-4405, 2019; PubMed: 30811189; DOI: 10.1021/jacs.8b13453

実験手法

X-RAY DIFFRACTION (2.349 Å)