6DYY

Crystal structure of Helicobacter pylori 5'-methylthioadenosine/S-adenosyl homocysteine nucleosidase (MTAN) complexed with (3R,4S)-1-((4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl)-4-(((3-(1-butyl-1H-1,2,3-triazol-4-yl)propyl)thio)methyl)pyrrolidin-3-ol

Summary for 6DYY

Entry DOI	10.2210/pdb6dyy/pdb
Descriptor	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, 1,2-ETHANEDIOL, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	mtan enzyme, duodenal ulcers, stomach cancer, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Helicobacter pylori (Campylobacter pylori)
Total number of polymer chains	4
Total formula weight	109808.97
Authors	Harijan, R.K.,Ducati, R.G.,Bonanno, J.B.,Almo, S.C.,Schramm, V.L. (deposition date: 2018-07-02, release date: 2019-03-20, Last modification date: 2023-10-11)
Primary citation	Harijan, R.K.,Hoff, O.,Ducati, R.G.,Firestone, R.S.,Hirsch, B.M.,Evans, G.B.,Schramm, V.L.,Tyler, P.C. Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. J. Med. Chem., 62:3286-3296, 2019 Cited by PubMed: 30860833 DOI: 10.1021/acs.jmedchem.8b01642 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.61 Å)

Structure validation