6DXT
Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoate
Summary for 6DXT
Entry DOI | 10.2210/pdb6dxt/pdb |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 5, 3-(5-phenyl-1,3,4-oxadiazol-2-yl)propanoic acid, UNKNOWN ATOM OR ION, ... (6 entities in total) |
Functional Keywords | deubiquitinase, usp5, ubiquitin, structural genomics consortium, sgc, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 27667.70 |
Authors | Mann, M.K.,Harding, R.J.,Ravichandran, M.,Ferreira de Freitas, R.,Franzoni, I.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.M.,Schapira, M.,Structural Genomics Consortium (SGC) (deposition date: 2018-06-29, release date: 2018-08-08, Last modification date: 2023-10-11) |
Primary citation | Mann, M.K.,Franzoni, I.,de Freitas, R.F.,Tempel, W.,Houliston, S.,Smith, L.,Vedadi, M.,Arrowsmith, C.H.,Harding, R.J.,Schapira, M. Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. J.Med.Chem., 62:10144-10155, 2019 Cited by PubMed: 31663737DOI: 10.1021/acs.jmedchem.9b00988 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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