6DXH

Structure of USP5 zinc-finger ubiquitin binding domain co-crystallized with 4-(4-tert-butylphenyl)-4-oxobutanoate

Summary for 6DXH

Entry DOI	10.2210/pdb6dxh/pdb
Descriptor	Ubiquitin carboxyl-terminal hydrolase 5, UNKNOWN ATOM OR ION, ZINC ION, ... (5 entities in total)
Functional Keywords	deubiquitinase, usp5, ubiquitin, structural genomics consortium, sgc, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	13834.90
Authors	Harding, R.J.,Mann, M.K.,Ravichandran, M.,Ferreira de Freitas, R.,Franzoni, I.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Schapira, M.,Structural Genomics Consortium (SGC) (deposition date: 2018-06-28, release date: 2018-07-18, Last modification date: 2023-10-11)
Primary citation	Mann, M.K.,Franzoni, I.,de Freitas, R.F.,Tempel, W.,Houliston, S.,Smith, L.,Vedadi, M.,Arrowsmith, C.H.,Harding, R.J.,Schapira, M. Discovery of Small Molecule Antagonists of the USP5 Zinc Finger Ubiquitin-Binding Domain. J.Med.Chem., 62:10144-10155, 2019 Cited by PubMed: 31663737 DOI: 10.1021/acs.jmedchem.9b00988 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation