6DWN

Structure of Human Cytochrome P450 1A1 with Erlotinib

Summary for 6DWN

Entry DOI	10.2210/pdb6dwn/pdb
Descriptor	Cytochrome P450 1A1, PROTOPORPHYRIN IX CONTAINING FE, [6,7-BIS(2-METHOXY-ETHOXY)QUINAZOLINE-4-YL]-(3-ETHYNYLPHENYL)AMINE, ... (5 entities in total)
Functional Keywords	ligand, oxidoreductase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	229046.07
Authors	Bart, A.G.,Scott, E.E. (deposition date: 2018-06-26, release date: 2018-10-03, Last modification date: 2023-10-11)
Primary citation	Bart, A.G.,Scott, E.E. Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands. J. Biol. Chem., 293:19201-19210, 2018 Cited by PubMed: 30254074 DOI: 10.1074/jbc.RA118.005588 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation