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6DW5

SAMHD1 Bound to Gemcitabine-TP in the Catalytic Pocket

Summary for 6DW5
Entry DOI10.2210/pdb6dw5/pdb
DescriptorDeoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), GUANOSINE-5'-TRIPHOSPHATE, ... (8 entities in total)
Functional Keywordscomplex, deoxynucleoside triphosphate triphosphohydrolase, dntpase, nucleotide analogue, gemcitabine-tp, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight260169.20
Authors
Primary citationKnecht, K.M.,Buzovetsky, O.,Schneider, C.,Thomas, D.,Srikanth, V.,Kaderali, L.,Tofoleanu, F.,Reiss, K.,Ferreiros, N.,Geisslinger, G.,Batista, V.S.,Ji, X.,Cinatl Jr., J.,Keppler, O.T.,Xiong, Y.
The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Proc. Natl. Acad. Sci. U.S.A., 115:E10022-E10031, 2018
Cited by
PubMed: 30305425
DOI: 10.1073/pnas.1805593115
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.93 Å)
Structure validation

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