6DVR

Crystal structure of human CARM1 with (R)-SKI-72

6DVR の概要

• エントリーDOI: 10.2210/pdb6dvr/pdb
• 分子名称: Histone-arginine methyltransferase CARM1, (2R,5S)-2-amino-6-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]-5-[(benzylamino)methyl]-N-[2-(4-methoxyphenyl)ethyl]hexanamide (non-preferred name), 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, ... (5 entities in total)
• 機能のキーワード: carm1, prmt4, ski-72 inhibitor, structural genomics, structural genomics consortium, sgc, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 79783.07

構造登録者

Dong, A.,Zeng, H.,Hutchinson, A.,Seitova, A.,Luo, M.,Cai, X.C.,Ke, W.,Wang, J.,Shi, C.,Zheng, W.,Lee, J.P.,Ibanez, G.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC) (登録日: 2018-06-25, 公開日: 2018-07-25, 最終更新日: 2023-10-11)

• 主引用文献: Zeng, H.,Dong, A.,Hutchinson, A.,Seitova, A.,Luo, M.,Cai, X.C.,Ke, W.,Wang, J.,Shi, C.,Zheng, W.,Lee, J.P.,Ibanez, G.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Brown, P.J.,Structural Genomics Consortium (SGC); Crystal structure of human CARM1 with (R)-SKI-72; to be published,

実験手法

X-RAY DIFFRACTION (1.54 Å)