6DUV
Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor
6DUV の概要
エントリーDOI | 10.2210/pdb6duv/pdb |
分子名称 | Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate, 1,2-ETHANEDIOL, ... (4 entities in total) |
機能のキーワード | protein-small molecule inhibitor complex, protein binding, protein binding-inhibitor complex, protein binding/inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 27753.54 |
構造登録者 | |
主引用文献 | Babault, N.,Zhang, Q.,Zhang, G.,Zhou, M.M.,Zeng, L. Role of Bound Water Molecules in Differential Recognition of Di-Acetylated Histone Peptides by the BRD4 Bromodomains To be published, |
実験手法 | X-RAY DIFFRACTION (1.8 Å) |
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