6DUV

Crystal structure of the second bromodomain of human BRD4 in complex with MS417 inhibitor

6DUV の概要

• エントリーDOI: 10.2210/pdb6duv/pdb
• 分子名称: Bromodomain-containing protein 4, methyl [(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetate, 1,2-ETHANEDIOL, ... (4 entities in total)
• 機能のキーワード: protein-small molecule inhibitor complex, protein binding, protein binding-inhibitor complex, protein binding/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27753.54

構造登録者

Babault, N.,Zhou, M.M. (登録日: 2018-06-22, 公開日: 2019-06-26, 最終更新日: 2024-03-13)

• 主引用文献: Babault, N.,Zhang, Q.,Zhang, G.,Zhou, M.M.,Zeng, L.; Role of Bound Water Molecules in Differential Recognition of Di-Acetylated Histone Peptides by the BRD4 Bromodomains; To be published,

実験手法

X-RAY DIFFRACTION (1.8 Å)