6DU8

Human Polycsytin 2-l1

Summary for 6DU8

• Entry DOI: 10.2210/pdb6du8/pdb
• EMDB information: 8912
• Descriptor: Polycystic kidney disease 2-like 1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• Functional Keywords: polycystic 2-l1, pc2l1, pkd2l1, trpp2, membrane protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 369167.36

Authors

Hulse, R.E.,Clapham, D.E.,Li, Z.,Huang, R.K.,Zhang, J. (deposition date: 2018-06-20, release date: 2018-07-25, Last modification date: 2024-12-25)

Primary citation

Hulse, R.E.,Li, Z.,Huang, R.K.,Zhang, J.,Clapham, D.E.
Cryo-EM structure of the polycystin 2-l1 ion channel.
Elife, 7:-, 2018

PubMed Abstract: We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.

PubMed: 30004384
DOI: 10.7554/eLife.36931

Experimental method

ELECTRON MICROSCOPY (3.11 Å)