6DU8

Human Polycsytin 2-l1

6DU8 の概要

• エントリーDOI: 10.2210/pdb6du8/pdb
• EMDBエントリー: 8912
• 分子名称: Polycystic kidney disease 2-like 1 protein, 2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• 機能のキーワード: polycystic 2-l1, pc2l1, pkd2l1, trpp2, membrane protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 369167.36

構造登録者

Hulse, R.E.,Clapham, D.E.,Li, Z.,Huang, R.K.,Zhang, J. (登録日: 2018-06-20, 公開日: 2018-07-25, 最終更新日: 2024-12-25)

主引用文献

Hulse, R.E.,Li, Z.,Huang, R.K.,Zhang, J.,Clapham, D.E.
Cryo-EM structure of the polycystin 2-l1 ion channel.
Elife, 7:-, 2018

PubMed Abstract: We report the near atomic resolution (3.3 Å) of the human polycystic kidney disease 2-like 1 (polycystin 2-l1) ion channel. Encoded by PKD2L1, polycystin 2-l1 is a calcium and monovalent cation-permeant ion channel in primary cilia and plasma membranes. The related primary cilium-specific polycystin-2 protein, encoded by PKD2, shares a high degree of sequence similarity, yet has distinct permeability characteristics. Here we show that these differences are reflected in the architecture of polycystin 2-l1.

PubMed: 30004384
DOI: 10.7554/eLife.36931

実験手法

ELECTRON MICROSCOPY (3.11 Å)