6DTC

Dihydrofolate Reductase (DHFR) of Aspergillus flavus in complex with a small molecule inhibitor

6DTC の概要

• エントリーDOI: 10.2210/pdb6dtc/pdb
• 関連するPDBエントリー: 6DRS
• 分子名称: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (3R)-3-methyl-4-[3-(1H-tetrazol-5-yl)phenoxy]-2,3-dihydrofuro[2,3-f]quinazoline-7,9-diamine, ... (5 entities in total)
• 機能のキーワード: antifolate, dhfr, antifungal protein, antifungal protein-inhibitor complex, antifungal protein/inhibitor
• 由来する生物種: Aspergillus flavus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29402.01

構造登録者

Bensen, D.C.,Fortier, J.M.,Akers-Rodriguez, S.,Tari, L.W. (登録日: 2018-06-15, 公開日: 2019-06-19, 最終更新日: 2023-10-11)

• 主引用文献: Bensen, D.C.,Fortier, J.M.,Akers-Rodriguez, S.,Tari, L.W.; Prospecting for broad-spectrum inhibitors of fungal dihydrofolate reductase using a structure guided approach.; To be published,

実験手法

X-RAY DIFFRACTION (2 Å)