Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | binding site for residue NAP A 301 |
| Chain | Residue |
| A | VAL11 |
| A | LYS65 |
| A | THR66 |
| A | VAL85 |
| A | THR86 |
| A | ARG87 |
| A | SER133 |
| A | ILE156 |
| A | GLY158 |
| A | ALA159 |
| A | GLU160 |
| A | ALA12 |
| A | ILE161 |
| A | TYR162 |
| A | H9G302 |
| A | HOH418 |
| A | HOH422 |
| A | HOH426 |
| A | HOH428 |
| A | HOH436 |
| A | HOH465 |
| A | HOH504 |
| A | ILE26 |
| A | HOH512 |
| A | GLY27 |
| A | GLY30 |
| A | THR31 |
| A | LEU32 |
| A | GLY63 |
| A | ARG64 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue H9G A 302 |
| Chain | Residue |
| A | ILE10 |
| A | VAL11 |
| A | ALA12 |
| A | ASP40 |
| A | MET41 |
| A | PHE44 |
| A | ALA45 |
| A | THR66 |
| A | LEU77 |
| A | ARG80 |
| A | ILE156 |
| A | TYR162 |
| A | THR179 |
| A | NAP301 |
| A | HOH431 |
| A | HOH452 |
| A | HOH478 |
| A | HOH595 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | GLY134 |
| A | LEU135 |
| A | GLU136 |
| A | THR164 |
| A | HOH425 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 304 |
| site_id | AC5 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 A 305 |
| Chain | Residue |
| A | ARG50 |
| A | HOH435 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 24 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGlngtLPWprikaDmsfFarvT |
| Chain | Residue | Details |
| A | GLY25-THR48 | |
