6DRY
Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor
Summary for 6DRY
Entry DOI | 10.2210/pdb6dry/pdb |
Descriptor | 5HT2B receptor, BRIL chimera, (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL, ... (8 entities in total) |
Functional Keywords | gpcr, 5ht2b, setotonin receptor, methylergonovine, membrane protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 47810.16 |
Authors | McCorvy, J.D.,Wacker, D.,Wang, S.,Agegnehu, B.,Liu, J.,Lansu, K.,Tribo, A.R.,Olsen, R.H.J.,Che, T.,Jin, J.,Roth, B.L. (deposition date: 2018-06-13, release date: 2018-08-29, Last modification date: 2023-10-11) |
Primary citation | McCorvy, J.D.,Wacker, D.,Wang, S.,Agegnehu, B.,Liu, J.,Lansu, K.,Tribo, A.R.,Olsen, R.H.J.,Che, T.,Jin, J.,Roth, B.L. Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25:787-796, 2018 Cited by PubMed: 30127358DOI: 10.1038/s41594-018-0116-7 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.918 Å) |
Structure validation
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