6DRY

Structural Determinants of Activation and Biased Agonism at the 5-HT2B Receptor

Summary for 6DRY

Entry DOI	10.2210/pdb6dry/pdb
Descriptor	5HT2B receptor, BRIL chimera, (8beta)-N-[(2S)-1-hydroxybutan-2-yl]-6-methyl-9,10-didehydroergoline-8-carboxamide, CHOLESTEROL, ... (8 entities in total)
Functional Keywords	gpcr, 5ht2b, setotonin receptor, methylergonovine, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	47810.16
Authors	McCorvy, J.D.,Wacker, D.,Wang, S.,Agegnehu, B.,Liu, J.,Lansu, K.,Tribo, A.R.,Olsen, R.H.J.,Che, T.,Jin, J.,Roth, B.L. (deposition date: 2018-06-13, release date: 2018-08-29, Last modification date: 2023-10-11)
Primary citation	McCorvy, J.D.,Wacker, D.,Wang, S.,Agegnehu, B.,Liu, J.,Lansu, K.,Tribo, A.R.,Olsen, R.H.J.,Che, T.,Jin, J.,Roth, B.L. Structural determinants of 5-HT2Breceptor activation and biased agonism. Nat. Struct. Mol. Biol., 25:787-796, 2018 Cited by PubMed: 30127358 DOI: 10.1038/s41594-018-0116-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.918 Å)

Structure validation