6DNE

Crystal structure of human Bromodomain-containing protein 4 (BRD4) bromodomain with MS660

6DNE の概要

• エントリーDOI: 10.2210/pdb6dne/pdb
• 分子名称: Bromodomain-containing protein 4, N,N'-[ethane-1,2-diylbis(oxyethane-2,1-diyl)]bis{2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetamide} (3 entities in total)
• 機能のキーワード: transcription, inhibitor, histone acetylation
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 98397.86

構造登録者

Ren, C.,Zhou, M.M. (登録日: 2018-06-06, 公開日: 2018-07-18, 最終更新日: 2023-10-11)

• 主引用文献: Ren, C.,Zhang, G.,Han, F.,Fu, S.,Cao, Y.,Zhang, F.,Zhang, Q.,Meslamani, J.,Xu, Y.,Ji, D.,Cao, L.,Zhou, Q.,Cheung, K.L.,Sharma, R.,Babault, N.,Yi, Z.,Zhang, W.,Walsh, M.J.,Zeng, L.,Zhou, M.M.; Spatially constrained tandem bromodomain inhibition bolsters sustained repression of BRD4 transcriptional activity for TNBC cell growth.; Proc. Natl. Acad. Sci. U.S.A., 115:7949-7954, 2018; PubMed: 30012592; DOI: 10.1073/pnas.1720000115

実験手法

X-RAY DIFFRACTION (2.958 Å)