6DN8
SPRY domain-containing SOCS box protein 2 complexed with (GZJ)VDINNN(CY3) Cyclic peptide inhibitor
Summary for 6DN8
Entry DOI | 10.2210/pdb6dn8/pdb |
Related PRD ID | PRD_002312 |
Descriptor | SPRY domain-containing SOCS box protein 4, (GZJ)VDINNN(CY3) Cyclic peptide inhibitor, ACETATE ION, ... (5 entities in total) |
Functional Keywords | proteasomal degradation, nitric oxide, inhibitor, immune system, immune system-inhibitor complex, immune system/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 78901.51 |
Authors | Law, R.H.P.,Caradoc-Davies, T.T.,Norton, R.S. (deposition date: 2018-06-06, release date: 2019-04-17, Last modification date: 2022-04-13) |
Primary citation | Sadek, M.M.,Barlow, N.,Leung, E.W.W.,Williams-Noonan, B.J.,Yap, B.K.,Shariff, F.M.,Caradoc-Davies, T.T.,Nicholson, S.E.,Chalmers, D.K.,Thompson, P.E.,Law, R.H.P.,Norton, R.S. A Cyclic Peptide Inhibitor of the iNOS-SPSB Protein-Protein Interaction as a Potential Anti-Infective Agent. ACS Chem. Biol., 13:2930-2938, 2018 Cited by PubMed: 30226743DOI: 10.1021/acschembio.8b00561 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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