Retrofitted antibodies with stabilizing mutations: Herceptin scFv mutant with VH K30D and VL S52D.

Replaces:  4X4Y

Summary for 6DN0

DescriptorHuman Variable Heavy Chain of Herceptin containing VH mutation K30D, Human Variable Light Chain of Herceptin containing VL mutation S52D, FORMIC ACID, ... (4 entities in total)
Functional Keywordsherceptin, retrofit, stabilizing mutation, immune system
Biological sourceHomo sapiens
Total number of polymer chains4
Total molecular weight51684.71
Langley, D.B.,Roome, B.,Christ, D. (deposition date: 2018-06-05, release date: 2019-06-12)
Primary citation
Roome, B.,Langley, D.B.,Rouet, R.,Christ, D.
Retrofitting antibodies with stabilizing mutations
To Be Published,
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21330 1.1% 5.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution