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6DM8

Understanding the Species Selectivity of Myeloid cell leukemia-1 (Mcl-1) inhibitors

Summary for 6DM8
Entry DOI10.2210/pdb6dm8/pdb
Related PRD IDPRD_900001
DescriptorInduced myeloid leukemia cell differentiation protein Mcl-1 homolog - MBP chimera, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, 4-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-6-carboxylic acid, ... (4 entities in total)
Functional Keywordsapoptosis, cancer, mcl-1, drug discovery, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
Biological sourceEscherichia coli (strain K12)
More
Total number of polymer chains8
Total formula weight479370.81
Authors
Zhao, B. (deposition date: 2018-06-04, release date: 2018-08-01, Last modification date: 2024-03-13)
Primary citationZhao, B.,Arnold, A.L.,Coronel, M.A.,Lee, J.H.,Lee, T.,Olejniczak, E.T.,Fesik, S.W.
Understanding the Species Selectivity of Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors.
Biochemistry, 57:4952-4958, 2018
Cited by
PubMed: 30011190
DOI: 10.1021/acs.biochem.8b00626
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.7 Å)
Structure validation

217705

数据于2024-03-27公开中

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