6DL7

Human mitochondrial ClpP in complex with ONC201 (TIC10)

Summary for 6DL7

Entry DOI	10.2210/pdb6dl7/pdb
Descriptor	ATP-dependent Clp protease proteolytic subunit, mitochondrial, 7-benzyl-4-[(2-methylphenyl)methyl]-6,7,8,9-tetrahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(4H)-one (3 entities in total)
Functional Keywords	protease, mitochondria, homeostasis, degradation, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	7
Total formula weight	171950.44
Authors	Halgas, O.,Zarabi, S.F.,Schimmer, A.,Pai, E.F. (deposition date: 2018-05-31, release date: 2019-05-08, Last modification date: 2024-03-13)
Primary citation	Ishizawa, J.,Zarabi, S.F.,Davis, R.E.,Halgas, O.,Nii, T.,Jitkova, Y.,Zhao, R.,St-Germain, J.,Heese, L.E.,Egan, G.,Ruvolo, V.R.,Barghout, S.H.,Nishida, Y.,Hurren, R.,Ma, W.,Gronda, M.,Link, T.,Wong, K.,Mabanglo, M.,Kojima, K.,Borthakur, G.,MacLean, N.,Ma, M.C.J.,Leber, A.B.,Minden, M.D.,Houry, W.,Kantarjian, H.,Stogniew, M.,Raught, B.,Pai, E.F.,Schimmer, A.D.,Andreeff, M. Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Cancer Cell, 35:721-, 2019 Cited by PubMed: 31056398 DOI: 10.1016/j.ccell.2019.03.014 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation