6DKJ
human GIPR ECD and Fab complex
Summary for 6DKJ
Entry DOI | 10.2210/pdb6dkj/pdb |
Descriptor | Fab heavy chain, Fab light chain, Gastric inhibitory polypeptide receptor, ... (5 entities in total) |
Functional Keywords | gpcr, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 121046.82 |
Authors | |
Primary citation | Killion, E.A.,Wang, J.,Yie, J.,Shi, S.D.,Bates, D.,Min, X.,Komorowski, R.,Hager, T.,Deng, L.,Atangan, L.,Lu, S.C.,Kurzeja, R.J.M.,Sivits, G.,Lin, J.,Chen, Q.,Wang, Z.,Thibault, S.A.,Abbott, C.M.,Meng, T.,Clavette, B.,Murawsky, C.M.,Foltz, I.N.,Rottman, J.B.,Hale, C.,Veniant, M.M.,Lloyd, D.J. Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models. Sci Transl Med, 10:-, 2018 Cited by PubMed: 30567927DOI: 10.1126/scitranslmed.aat3392 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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