6DI4

Rational Modification of Vanillin Derivatives to Stereospecifically Destabilize Sickle Hemoglobin Polymer Formation

6DI4 の概要

• エントリーDOI: 10.2210/pdb6di4/pdb
• 分子名称: Hemoglobin subunit alpha, Hemoglobin subunit beta, CARBON MONOXIDE, ... (6 entities in total)
• 機能のキーワード: hemoglobin, relaxed state, sickle cell disease, aromatic aldehyde, antisickling, oxygen transport
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 65177.69

構造登録者

Pagare, P.P.,Musayev, F.N. (登録日: 2018-05-22, 公開日: 2018-09-05, 最終更新日: 2019-12-04)

• 主引用文献: Deshpande, T.M.,Pagare, P.P.,Ghatge, M.S.,Chen, Q.,Musayev, F.N.,Venitz, J.,Zhang, Y.,Abdulmalik, O.,Safo, M.K.; Rational modification of vanillin derivatives to stereospecifically destabilize sickle hemoglobin polymer formation.; Acta Crystallogr D Struct Biol, 74:956-964, 2018; PubMed: 30289405; DOI: 10.1107/S2059798318009919

実験手法

X-RAY DIFFRACTION (1.9 Å)