6DHA
Crystal Structure of Human PPARgamma Ligand Binding Domain in Complex with Hydroxy Pioglitazone (M-IV)
6DHA の概要
エントリーDOI | 10.2210/pdb6dha/pdb |
分子名称 | Peroxisome proliferator-activated receptor gamma, Hydroxy Pioglitazone (M-IV), nonanoic acid, ... (4 entities in total) |
機能のキーワード | nuclear receptors, tzds, drug design, therapeutic targets, transcription, transcription-transcription inhibitor complex, transcription/transcription inhibitor |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 63055.39 |
構造登録者 | |
主引用文献 | Mosure, S.A.,Shang, J.,Eberhardt, J.,Brust, R.,Zheng, J.,Griffin, P.R.,Forli, S.,Kojetin, D.J. Structural Basis of Altered Potency and Efficacy Displayed by a Major in Vivo Metabolite of the Antidiabetic PPAR gamma Drug Pioglitazone. J. Med. Chem., 62:2008-2023, 2019 Cited by PubMed: 30676741DOI: 10.1021/acs.jmedchem.8b01573 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.88 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード