Kaiso (ZBTB33) E535Q zinc finger DNA binding domain in complex with the specific Kaiso binding sequence (KBS)

Summary for 6DF9

Related6DF5 6DF8
DescriptorTranscriptional regulator Kaiso, DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*GP*GP*AP*AP*GP*CP*A)-3'), ... (6 entities in total)
Functional Keywordsdna methylation, zinc finger, transcriptional regulator, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight27480.64
Nikolova, E.N.,Stanfield, R.L.,Dyson, H.J.,Wright, P.E. (deposition date: 2018-05-14, release date: 2019-05-22, Last modification date: 2020-05-13)
Primary citation
Nikolova, E.N.,Stanfield, R.L.,Dyson, H.J.,Wright, P.E.
A conformational switch in the zinc finger protein Kaiso mediates differential readout of specific and methylated DNA sequences.
Biochemistry, 2020
PubMed: 32352758 (PDB entries with the same primary citation)
DOI: 10.1021/acs.biochem.0c00253
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.219200 7.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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