6DDP
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid
Summary for 6DDP
Entry DOI | 10.2210/pdb6ddp/pdb |
Related | 5JA3 |
Descriptor | Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid, ... (4 entities in total) |
Functional Keywords | dhfr, antifolate, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
Total number of polymer chains | 4 |
Total formula weight | 75291.54 |
Authors | Hajian, B.,Wright, D. (deposition date: 2018-05-10, release date: 2018-05-23, Last modification date: 2023-10-11) |
Primary citation | Hajian, B.,Scocchera, E.,Shoen, C.,Krucinska, J.,Viswanathan, K.,G-Dayanandan, N.,Erlandsen, H.,Estrada, A.,Mikusova, K.,Kordulakova, J.,Cynamon, M.,Wright, D. Drugging the Folate Pathway in Mycobacterium tuberculosis: The Role of Multi-targeting Agents. Cell Chem Biol, 26:781-791.e6, 2019 Cited by PubMed: 30930162DOI: 10.1016/j.chembiol.2019.02.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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