6DDP
Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Dihydrofolate reductase | polymer | 159 | 17661.0 | 4 | UniProt (P9WNX1) Pfam (PF00186) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | |
| 2 | E, G, J, K (A, B, C, D) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 4 | Chemie (NDP) | |||
| 3 | F, H, I, L (A, B, C, D) | 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid | non-polymer | 416.5 | 4 | Chemie (G6Y) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 307 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 70644.0 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4647.6 | |
| All* | Total formula weight | 75291.5 |
