6DDP

Mycobacterium tuberculosis Dihydrofolate Reductase complexed with beta-NADPH and 3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	Dihydrofolate reductase	polymer	159	17661.0	4	UniProt (P9WNX1) Pfam (PF00186) In PDB	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
2	A, B, C, D	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	4	Chemie (NDP)
3	A, B, C, D	3'-[(2R)-4-(2,4-diamino-6-ethylpyrimidin-5-yl)but-3-yn-2-yl]-5'-methoxy[1,1'-biphenyl]-4-carboxylic acid	non-polymer		416.5	4	Chemie (G6Y)
4		water	water		18.0	307	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	70644.0
Non-Polymers*	Number of molecules	8
	Total formula weight	4647.6
All*	Total formula weight	75291.5

*Water molecules are not included.