6DD9

Structure of mouse SYCP3, P1 form

Summary for 6DD9

• Entry DOI: 10.2210/pdb6dd9/pdb
• Related: 6DD8
• Descriptor: Synaptonemal complex protein 3 (2 entities in total)
• Functional Keywords: meiosis, chromosome axis, coiled-coil, structural protein
• Biological source: Mus musculus (Mouse)
• Total number of polymer chains: 4
• Total formula weight: 71296.50

Authors

Rosenberg, S.C.,Munoz, I.C.,Uson, I.,Corbett, K.D. (deposition date: 2018-05-09, release date: 2018-08-01, Last modification date: 2024-11-20)

Primary citation

West, A.M.,Rosenberg, S.C.,Ur, S.N.,Lehmer, M.K.,Ye, Q.,Hagemann, G.,Caballero, I.,Uson, I.,MacQueen, A.J.,Herzog, F.,Corbett, K.D.
A conserved filamentous assembly underlies the structure of the meiotic chromosome axis.
Elife, 8:-, 2019

PubMed Abstract: The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged. Here, we show that 'axis core proteins' from budding yeast (Red1), mammals (SYCP2/SYCP3), and plants (ASY3/ASY4) are evolutionarily related and play equivalent roles in chromosome axis assembly. We first identify 'closure motifs' in each complex that recruit meiotic HORMADs, the master regulators of meiotic recombination. We next find that axis core proteins form homotetrameric (Red1) or heterotetrameric (SYCP2:SYCP3 and ASY3:ASY4) coiled-coil assemblies that further oligomerize into micron-length filaments. Thus, the meiotic chromosome axis core in fungi, mammals, and plants shares a common molecular architecture, and likely also plays conserved roles in meiotic chromosome axis assembly and recombination control.

PubMed: 30657449
DOI: 10.7554/eLife.40372

Experimental method

X-RAY DIFFRACTION (2.3 Å)