6DD9

Structure of mouse SYCP3, P1 form

6DD9 の概要

• エントリーDOI: 10.2210/pdb6dd9/pdb
• 関連するPDBエントリー: 6DD8
• 分子名称: Synaptonemal complex protein 3 (2 entities in total)
• 機能のキーワード: meiosis, chromosome axis, coiled-coil, structural protein
• 由来する生物種: Mus musculus (Mouse)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 71296.50

構造登録者

Rosenberg, S.C.,Munoz, I.C.,Uson, I.,Corbett, K.D. (登録日: 2018-05-09, 公開日: 2018-08-01, 最終更新日: 2024-11-20)

主引用文献

West, A.M.,Rosenberg, S.C.,Ur, S.N.,Lehmer, M.K.,Ye, Q.,Hagemann, G.,Caballero, I.,Uson, I.,MacQueen, A.J.,Herzog, F.,Corbett, K.D.
A conserved filamentous assembly underlies the structure of the meiotic chromosome axis.
Elife, 8:-, 2019

PubMed Abstract: The meiotic chromosome axis plays key roles in meiotic chromosome organization and recombination, yet the underlying protein components of this structure are highly diverged. Here, we show that 'axis core proteins' from budding yeast (Red1), mammals (SYCP2/SYCP3), and plants (ASY3/ASY4) are evolutionarily related and play equivalent roles in chromosome axis assembly. We first identify 'closure motifs' in each complex that recruit meiotic HORMADs, the master regulators of meiotic recombination. We next find that axis core proteins form homotetrameric (Red1) or heterotetrameric (SYCP2:SYCP3 and ASY3:ASY4) coiled-coil assemblies that further oligomerize into micron-length filaments. Thus, the meiotic chromosome axis core in fungi, mammals, and plants shares a common molecular architecture, and likely also plays conserved roles in meiotic chromosome axis assembly and recombination control.

PubMed: 30657449
DOI: 10.7554/eLife.40372

実験手法

X-RAY DIFFRACTION (2.3 Å)