6DCB

Structure of methylphosphate capping enzyme methyltransferase domain in complex with 5' end of 7SK RNA

Summary for 6DCB

• Entry DOI: 10.2210/pdb6dcb/pdb
• Descriptor: human 7SK RNA stem-loop 1 proximal, 7SK snRNA methylphosphate capping enzyme, S-ADENOSYL-L-HOMOCYSTEINE, ... (5 entities in total)
• Functional Keywords: rna methyl transferase, mepce, 7sk rna, transferase-rna complex, transferase/rna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 47505.22

Authors

Yang, Y.,Eichhorn, C.,Cascio, D.,Feigon, J. (deposition date: 2018-05-04, release date: 2018-12-19, Last modification date: 2023-10-11)

• Primary citation: Yang, Y.,Eichhorn, C.D.,Wang, Y.,Cascio, D.,Feigon, J.; Structural basis of 7SK RNA 5'-gamma-phosphate methylation and retention by MePCE.; Nat. Chem. Biol., 15:132-140, 2019; PubMed: 30559425; DOI: 10.1038/s41589-018-0188-z

Experimental method

X-RAY DIFFRACTION (1.998 Å)