6DAV

Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate

Summary for 6DAV

• Entry DOI: 10.2210/pdb6dav/pdb
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-(4-{[(2,4-diaminopteridin-6-yl)methyl](hydroxymethyl)amino}benzene-1-carbonyl)-L-glutamic acid, ... (5 entities in total)
• Functional Keywords: structure-guided drug discovery consortium, dihydrofolate reductase, hdhfr, nadp, oxidoreductase
• Biological source: Homo sapiens (Human)
• Cellular location: Mitochondrion : P00374
• Total number of polymer chains: 2
• Total formula weight: 45575.34

Authors

Mayclin, S.J.,Dranow, D.M.,Lorimer, D.D. (deposition date: 2018-05-02, release date: 2018-05-16, Last modification date: 2024-03-13)

• Primary citation: Mayclin, S.J.,Dranow, D.M.,Walpole, C.,Lorimer, D.D.; Crystal Structure of Human DHFR complexed with NADP and N10formyltetrahydrofolate; to be published,

Experimental method

X-RAY DIFFRACTION (1.55 Å)