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6DAL

Human CYP3A4 bound to an inhibitor

Summary for 6DAL
Entry DOI10.2210/pdb6dal/pdb
DescriptorCytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (4 entities in total)
Functional Keywordsoxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight56969.04
Authors
Sevrioukova, I.F. (deposition date: 2018-05-01, release date: 2019-04-03, Last modification date: 2023-10-04)
Primary citationSamuels, E.R.,Sevrioukova, I.
Structure-Activity Relationships of Rationally Designed Ritonavir Analogues: Impact of Side-Group Stereochemistry, Headgroup Spacing, and Backbone Composition on the Interaction with CYP3A4.
Biochemistry, 58:2077-2087, 2019
Cited by
PubMed: 30912932
DOI: 10.1021/acs.biochem.9b00156
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.65 Å)
Structure validation

217705

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