6D9H

Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist

6D9H の概要

• エントリーDOI: 10.2210/pdb6d9h/pdb
• EMDBエントリー: 7835
• 分子名称: Guanine nucleotide-binding protein G(i) subunit alpha-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (5 entities in total)
• 機能のキーワード: signaling protein, membrane protein, active-state g protein-coupled receptor, adenosine a1 receptor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 130702.62

構造登録者

Draper-Joyce, C.J.,Khoshouei, M.,Thal, D.M.,Liang, Y.-L.,Nguyen, A.T.N.,Furness, S.G.B.,Venugopal, H.,Baltos, J.,Plitzko, J.M.,Danev, R.,Baumeister, W.,May, L.T.,Wootten, D.,Sexton, P.,Glukhova, A.,Christopoulos, A. (登録日: 2018-04-29, 公開日: 2018-06-20, 最終更新日: 2018-07-11)

• 主引用文献: Draper-Joyce, C.J.,Khoshouei, M.,Thal, D.M.,Liang, Y.L.,Nguyen, A.T.N.,Furness, S.G.B.,Venugopal, H.,Baltos, J.A.,Plitzko, J.M.,Danev, R.,Baumeister, W.,May, L.T.,Wootten, D.,Sexton, P.M.,Glukhova, A.,Christopoulos, A.; Structure of the adenosine-bound human adenosine A1receptor-Gicomplex.; Nature, 558:559-563, 2018; PubMed: 29925945; DOI: 10.1038/s41586-018-0236-6

実験手法

ELECTRON MICROSCOPY (3.6 Å)