6D78

The complex between high-affinity TCR DMF5(alpha-D26Y,beta-L98W) and human Class I MHC HLA-A2 with the bound MART-1(27-35)peptide

6D78 の概要

• エントリーDOI: 10.2210/pdb6d78/pdb
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Melanoma antigen recognized by T-cells 1, ... (6 entities in total)
• 機能のキーワード: alpha-beta t-cell receptor bound to class i mhc (hla-a2) in complex with the mart-1 peptide, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 93997.49

構造登録者

Hellman, L.M.,Singh, N.K. (登録日: 2018-04-24, 公開日: 2019-04-03, 最終更新日: 2023-10-04)

• 主引用文献: Hellman, L.M.,Foley, K.C.,Singh, N.K.,Alonso, J.A.,Riley, T.P.,Devlin, J.R.,Ayres, C.M.,Keller, G.L.J.,Zhang, Y.,Vander Kooi, C.W.,Nishimura, M.I.,Baker, B.M.; Improving T Cell Receptor On-Target Specificity via Structure-Guided Design.; Mol. Ther., 27:300-313, 2019; PubMed: 30617019; DOI: 10.1016/j.ymthe.2018.12.010

実験手法

X-RAY DIFFRACTION (2.347 Å)