Cryo-EM structure of the zebrafish TRPM2 channel in the presence of Ca2+

Summary for 6D73

EMDB information7822
DescriptorTransient receptor potential cation channel, subfamily M, CALCIUM ION (2 entities in total)
Functional Keywordswarmth sensor, redox sensor, calcium-permeable ion channel, ion channel, transport protein
Biological sourceDanio rerio (Zebrafish)
Total number of polymer chains4
Total molecular weight670594.81
Yin, Y.,Wu, M.,Borschel, W.F.,Lander, G.C.,Lee, S.-Y. (deposition date: 2018-04-23, release date: 2019-05-15, Last modification date: 2019-12-18)
Primary citation
Yin, Y.,Wu, M.,Hsu, A.L.,Borschel, W.F.,Borgnia, M.J.,Lander, G.C.,Lee, S.Y.
Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel.
Nat Commun, 10:3740-3740, 2019
PubMed: 31431622 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-11733-5
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers7 0.1% 1.5%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures
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