6D1B
Crystal structure of NDM-1 complexed with compound 2
Summary for 6D1B
Entry DOI | 10.2210/pdb6d1b/pdb |
Descriptor | Metallo-beta-lactamase type 2, ZINC ION, [(7-methoxy-2-oxo-2H-1-benzopyran-4-yl)methyl]phosphonic acid, ... (5 entities in total) |
Functional Keywords | beta-lactamase, carbapenemase, phosphonate, inhibitor, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 25121.76 |
Authors | Pemberton, O.A.,Chen, Y. (deposition date: 2018-04-11, release date: 2019-04-17, Last modification date: 2023-10-04) |
Primary citation | Pemberton, O.A.,Jaishankar, P.,Akhtar, A.,Adams, J.L.,Shaw, L.N.,Renslo, A.R.,Chen, Y. Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. J.Med.Chem., 62:8480-8496, 2019 Cited by PubMed: 31483651DOI: 10.1021/acs.jmedchem.9b00728 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.25 Å) |
Structure validation
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