6CZU
BRD4(BD1) complexed with 3219
Summary for 6CZU
Entry DOI | 10.2210/pdb6czu/pdb |
Descriptor | Bromodomain-containing protein 4, 5-(3,5-dimethyl-1,2-oxazol-4-yl)-1-({4-[(1R)-1-hydroxyethyl]phenyl}methyl)pyridin-2(1H)-one, 1,2-ETHANEDIOL, ... (5 entities in total) |
Functional Keywords | bromodomain, brd4, transcription-inhibitor complex, transcription/inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 16166.58 |
Authors | Lakshminarasimhan, D.,White, A.,Suto, R.K. (deposition date: 2018-04-09, release date: 2018-09-26, Last modification date: 2018-10-10) |
Primary citation | Kharenko, O.A.,Patel, R.G.,Brown, S.D.,Calosing, C.,White, A.,Lakshminarasimhan, D.,Suto, R.K.,Duffy, B.C.,Kitchen, D.B.,McLure, K.G.,Hansen, H.C.,van der Horst, E.H.,Young, P.R. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J. Med. Chem., 61:8202-8211, 2018 Cited by PubMed: 30165024DOI: 10.1021/acs.jmedchem.8b00666 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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