6CZP

2.2 Angstrom Resolution Crystal Structure Oxygen-Insensitive NAD(P)H-dependent Nitroreductase NfsB from Vibrio vulnificus in Complex with FMN

Summary for 6CZP

• Entry DOI: 10.2210/pdb6czp/pdb
• Descriptor: Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... (7 entities in total)
• Functional Keywords: structural genomics, center for structural genomics of infectious diseases, csgid, oxygen-insensitive nitroreductase, oxidoreductase
• Biological source: Vibrio vulnificus
• Total number of polymer chains: 8
• Total formula weight: 200655.88

Authors

Minasov, G.,Wawrzak, Z.,Skarina, T.,Grimshaw, S.,Kwon, K.,Savchenko, A.,Satchell, K.J.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2018-04-09, release date: 2018-04-25, Last modification date: 2026-02-11)

Primary citation

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, 14:e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

Experimental method

X-RAY DIFFRACTION (2.24 Å)