6CZ4

Structure of the PTK6 kinase domain bound to a type II inhibitor 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide

6CZ4 の概要

• エントリーDOI: 10.2210/pdb6cz4/pdb
• 分子名称: Protein-tyrosine kinase 6, 2-{[(3R,4S)-3-fluoro-1-{[4-(trifluoromethoxy)phenyl]acetyl}piperidin-4-yl]oxy}-5-(1-methyl-1H-imidazol-4-yl)pyridine-3-carboxamide (3 entities in total)
• 機能のキーワード: protein kinase, ptk6, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30770.37

構造登録者

Gajiwala, K.S.,Johnson, E.,Cronin, C.N. (登録日: 2018-04-07, 公開日: 2018-06-20, 最終更新日: 2024-03-13)

• 主引用文献: Qiu, L.,Levine, K.,Gajiwala, K.S.,Cronin, C.N.,Nagata, A.,Johnson, E.,Kraus, M.,Tatlock, J.,Kania, R.,Foley, T.,Sun, S.; Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.; PLoS ONE, 13:e0198374-e0198374, 2018; PubMed: 29879184; DOI: 10.1371/journal.pone.0198374

実験手法

X-RAY DIFFRACTION (1.5 Å)