6CYU

Crystal structure of CTX-M-14 S70G/N106S/D240G beta-lactamase in complex with hydrolyzed cefotaxime

Summary for 6CYU

Entry DOI	10.2210/pdb6cyu/pdb
Related	6CYQ
Descriptor	Beta-lactamase, (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro -2H-1,3-thiazine-4-carboxylic acid (3 entities in total)
Functional Keywords	beta-lactamase ctx-m-14, hydrolase-hydrolase inhibitor complex, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	28298.89
Authors	Patel, M.P.,Hu, L.,Sankaran, B.,Brown, C.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2018-04-06, release date: 2018-10-10, Last modification date: 2023-10-04)
Primary citation	Patel, M.P.,Hu, L.,Brown, C.A.,Sun, Z.,Adamski, C.J.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. Synergistic effects of functionally distinct substitutions in beta-lactamase variants shed light on the evolution of bacterial drug resistance. J. Biol. Chem., 293:17971-17984, 2018 Cited by PubMed: 30275013 DOI: 10.1074/jbc.RA118.003792 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation