6CYU
Crystal structure of CTX-M-14 S70G/N106S/D240G beta-lactamase in complex with hydrolyzed cefotaxime
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-lactamase | polymer | 263 | 27885.5 | 1 | UniProt (Q9L5C7) Pfam (PF00144) Pfam (PF13354) UniProt (by SIFTS) (Q9L5C8) In PDB | Escherichia coli | |
| 2 | A | (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro -2H-1,3-thiazine-4-carboxylic acid | non-polymer | 413.4 | 1 | Chemie (CE4) | |||
| 3 | water | water | 18.0 | 281 | Chemie (HOH) |
Sequence modifications
A: 25 - 290 (UniProt: Q9L5C7)
| PDB | External Database | Details |
|---|---|---|
| Gly 70 | Ser 73 | engineered mutation |
| Ser 106 | Asn 109 | engineered mutation |
| Gly 240 | Asp 242 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 27885.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 413.4 | |
| All* | Total formula weight | 28298.9 |
