Crystal structure of CTX-M-14 S70G/N106S/D240G beta-lactamase in complex with hydrolyzed cefotaxime

Summary for 6CYU

DescriptorBeta-lactamase, (2R)-2-[(R)-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino}(carboxy)methyl]-5-methylidene-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid (3 entities in total)
Functional Keywordsbeta-lactamase ctx-m-14, hydrolase-hydrolase inhibitor complex, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceEscherichia coli
Total number of polymer chains1
Total molecular weight28298.89
Patel, M.P.,Hu, L.,Brown, C.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2018-04-06, release date: 2018-10-10, Last modification date: 2018-11-28)
Primary citation
Patel, M.P.,Hu, L.,Brown, C.A.,Sun, Z.,Adamski, C.J.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T.
Synergistic effects of functionally distinct substitutions in beta-lactamase variants shed light on the evolution of bacterial drug resistance.
J. Biol. Chem., 293:17971-17984, 2018
PubMed: 30275013 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.003792
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.20020 0.5% 1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6cyu
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Molmil generated image of 6cyu
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Molmil generated image of 6cyu
rotated about y axis by 90°
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