6CXL

anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5

Summary for 6CXL

• Entry DOI: 10.2210/pdb6cxl/pdb
• Descriptor: anti-HIV-1 Fab 2G12 light chain, anti-HIV-1 Fab 2G12 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose (3 entities in total)
• Functional Keywords: antibody, glycopeptide, hiv-1, glycobiology, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 4
• Total formula weight: 97049.83

Authors

Stanfield, R.L.,Wilson, I.A. (deposition date: 2018-04-03, release date: 2019-02-20, Last modification date: 2020-07-29)

• Primary citation: Nguyen, D.N.,Xu, B.,Stanfield, R.L.,Bailey, J.K.,Horiya, S.,Temme, J.S.,Leon, D.R.,LaBranche, C.C.,Montefiori, D.C.,Costello, C.E.,Wilson, I.A.,Krauss, I.J.; Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.; ACS Cent Sci, 5:237-249, 2019; PubMed: 30834312; DOI: 10.1021/acscentsci.8b00588

Experimental method

X-RAY DIFFRACTION (3.586 Å)