6CXL

anti-HIV-1 Fab 2G12 in complex with glycopeptide 10F5

6CXL の概要

• エントリーDOI: 10.2210/pdb6cxl/pdb
• 分子名称: anti-HIV-1 Fab 2G12 light chain, anti-HIV-1 Fab 2G12 heavy chain, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose (3 entities in total)
• 機能のキーワード: antibody, glycopeptide, hiv-1, glycobiology, immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 97049.83

構造登録者

Stanfield, R.L.,Wilson, I.A. (登録日: 2018-04-03, 公開日: 2019-02-20, 最終更新日: 2020-07-29)

• 主引用文献: Nguyen, D.N.,Xu, B.,Stanfield, R.L.,Bailey, J.K.,Horiya, S.,Temme, J.S.,Leon, D.R.,LaBranche, C.C.,Montefiori, D.C.,Costello, C.E.,Wilson, I.A.,Krauss, I.J.; Oligomannose Glycopeptide Conjugates Elicit Antibodies Targeting the Glycan Core Rather than Its Extremities.; ACS Cent Sci, 5:237-249, 2019; PubMed: 30834312; DOI: 10.1021/acscentsci.8b00588

実験手法

X-RAY DIFFRACTION (3.586 Å)