6CXK
E. coli DHFR substrate complex with Dihydrofolate
Summary for 6CXK
| Entry DOI | 10.2210/pdb6cxk/pdb |
| Related | 6CQA 6CW7 |
| Descriptor | Dihydrofolate reductase, MAGNESIUM ION, CHLORIDE ION, ... (5 entities in total) |
| Functional Keywords | dhfr, dihydrofolate reductase, dihydrofolate, complex, oxidoreductase |
| Biological source | Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC) |
| Total number of polymer chains | 1 |
| Total formula weight | 19521.53 |
| Authors | Cao, H.,Rodrigues, J.,Benach, J.,Frommelt, A.,Morisco, L.,Koss, J.,Shakhnovich, E.,Skolnick, J. (deposition date: 2018-04-03, release date: 2019-01-09, Last modification date: 2023-10-04) |
| Primary citation | Cao, H.,Gao, M.,Zhou, H.,Skolnick, J. The crystal structure of a tetrahydrofolate-bound dihydrofolate reductase reveals the origin of slow product release. Commun Biol, 1:226-226, 2018 Cited by PubMed: 30564747DOI: 10.1038/s42003-018-0236-y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.108 Å) |
Structure validation
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