6CWY

Crystal structure of SUMO E1 in complex with an allosteric inhibitor

6CWY の概要

• エントリーDOI: 10.2210/pdb6cwy/pdb
• 分子名称: SUMO-activating enzyme subunit 1, SUMO-activating enzyme subunit 2, GLYCEROL, ... (8 entities in total)
• 機能のキーワード: rossmann-like fold, ubiquitin-like fold, ubiquitin activating enzyme, activity, atp binding, ligase activity, atp/mg binding, ubiquitin e2, ligase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 113065.32

構造登録者

Lv, Z.,Yuan, L.,Atkison, J.H.,Williams, K.M.,Olsen, S.K. (登録日: 2018-04-01, 公開日: 2019-01-16, 最終更新日: 2023-10-04)

• 主引用文献: Lv, Z.,Yuan, L.,Atkison, J.H.,Williams, K.M.,Vega, R.,Sessions, E.H.,Divlianska, D.B.,Davies, C.,Chen, Y.,Olsen, S.K.; Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme.; Nat Commun, 9:5145-5145, 2018; PubMed: 30514846; DOI: 10.1038/s41467-018-07015-1

実験手法

X-RAY DIFFRACTION (2.462 Å)