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6CVH

Identification and biological evaluation of thiazole-based inverse agonists of RORgt

Summary for 6CVH
Entry DOI10.2210/pdb6cvh/pdb
DescriptorNuclear receptor ROR-gamma, trans-3-({4-(cyclohexylmethyl)-5-[3-(1-methylcyclopropyl)-5-{[(2R)-1,1,1-trifluoropropan-2-yl]carbamoyl}phenyl]-1,3-thiazole-2-carbonyl}amino)cyclobutane-1-carboxylic acid (2 entities in total)
Functional Keywordsnuclear receptor rorgt, nuclear protein
Biological sourceHomo sapiens (Human)
Cellular locationNucleus : P51449
Total number of polymer chains1
Total formula weight27027.29
Authors
Spurlino, J.,Milligan, C. (deposition date: 2018-03-28, release date: 2018-04-25, Last modification date: 2024-03-13)
Primary citationGege, C.,Cummings, M.D.,Albers, M.,Kinzel, O.,Kleymann, G.,Schluter, T.,Steeneck, C.,Nelen, M.I.,Milligan, C.,Spurlino, J.,Xue, X.,Leonard, K.,Edwards, J.P.,Fourie, A.,Goldberg, S.D.,Hoffmann, T.
Identification and biological evaluation of thiazole-based inverse agonists of ROR gamma t.
Bioorg. Med. Chem. Lett., 28:1446-1455, 2018
Cited by
PubMed: 29631962
DOI: 10.1016/j.bmcl.2018.03.093
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.5 Å)
Structure validation

217705

數據於2024-03-27公開中

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