6CUZ

Engineered TrpB from Pyrococcus furiosus, PfTrpB7E6 with (2S,3R)-ethylserine bound as the amino-acrylate

Summary for 6CUZ

• Entry DOI: 10.2210/pdb6cuz/pdb
• Descriptor: Tryptophan synthase beta chain 1, SODIUM ION, (2E)-2-[(E)-({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene)amino]pent-2-enoic acid, ... (6 entities in total)
• Functional Keywords: amino-acrylate, (2s, 3r)-ethylserine, lyase
• Biological source: Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1); More
• Total number of polymer chains: 4
• Total formula weight: 170823.45

Authors

Scheele, R.A.,Buller, A.R.,Boville, C.E.,Arnold, F.H. (deposition date: 2018-03-27, release date: 2018-09-26, Last modification date: 2023-11-15)

• Primary citation: Boville, C.E.,Scheele, R.A.,Koch, P.,Brinkmann-Chen, S.,Buller, A.R.,Arnold, F.H.; Engineered Biosynthesis of beta-Alkyl Tryptophan Analogues.; Angew. Chem. Int. Ed. Engl., 57:14764-14768, 2018; PubMed: 30215880; DOI: 10.1002/anie.201807998

Experimental method

X-RAY DIFFRACTION (1.75 Å)