6CUR

Ras:SOS:Ras in complex with a small molecule activator

Summary for 6CUR

DescriptorGTPase HRas, Son of sevenless homolog 1, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (10 entities in total)
Functional Keywordsras, sos, inhibitor, oncoprotein, protein-protein complex, mapk, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains3
Total molecular weight95845.94
Authors
Phan, J.,Abbott, J.,Fesik, S.W. (deposition date: 2018-03-26, release date: 2019-02-06)
Primary citation
Abbott, J.R.,Patel, P.A.,Howes, J.E.,Akan, D.T.,Kennedy, J.P.,Burns, M.C.,Browning, C.F.,Sun, Q.,Rossanese, O.W.,Phan, J.,Waterson, A.G.,Fesik, S.W.
Discovery of Quinazolines That Activate SOS1-Mediated Nucleotide Exchange on RAS.
ACS Med Chem Lett, 9:941-946, 2018
PubMed: 30258545 (PDB entries with the same primary citation)
DOI: 10.1021/acsmedchemlett.8b00296
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.73 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.1763 0.1% 1.5% 2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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