6CU8

Alpha Synuclein fibril formed by full length protein - Twister Polymorph

Summary for 6CU8

• Entry DOI: 10.2210/pdb6cu8/pdb
• Related: 6CU7
• EMDB information: 7619
• Descriptor: Alpha-synuclein (1 entity in total)
• Functional Keywords: parkinson's disease, synucleinopathy, amyloid aggregation, fibril polymorphism, protein fibril
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 10
• Total formula weight: 144761.08

Authors

Li, B.,Hatami, A.,Ge, P.,Murray, K.A.,Sheth, P.,Zhang, M.,Nair, G.,Sawaya, M.R.,Zhu, C.,Broad, M.,Shin, W.S.,Ye, S.,John, V.,Eisenberg, D.S.,Zhou, Z.H.,Jiang, L. (deposition date: 2018-03-23, release date: 2018-09-12, Last modification date: 2024-03-13)

• Primary citation: Li, B.,Ge, P.,Murray, K.A.,Sheth, P.,Zhang, M.,Nair, G.,Sawaya, M.R.,Shin, W.S.,Boyer, D.R.,Ye, S.,Eisenberg, D.S.,Zhou, Z.H.,Jiang, L.; Cryo-EM of full-length alpha-synuclein reveals fibril polymorphs with a common structural kernel.; Nat Commun, 9:3609-3609, 2018; PubMed: 30190461; DOI: 10.1038/s41467-018-05971-2

Experimental method

ELECTRON MICROSCOPY (3.6 Å)