6CTK

Ternary complex crystal structure of DNA polymerase Beta with a dideoxy terminated primer with CHF-R/S isomers, beta, gamma dTTP analogue

Summary for 6CTK

• Entry DOI: 10.2210/pdb6ctk/pdb
• Descriptor: DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... (8 entities in total)
• Functional Keywords: dna polymerase beta, conformational change, enzyme mechanism, lfer, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 48309.41

Authors

Batra, V.K.,Wilson, S.H. (deposition date: 2018-03-23, release date: 2018-06-20, Last modification date: 2023-10-04)

• Primary citation: Batra, V.K.,Oertell, K.,Beard, W.A.,Kashemirov, B.A.,McKenna, C.E.,Goodman, M.F.,Wilson, S.H.; Mapping Functional Substrate-Enzyme Interactions in the pol beta Active Site through Chemical Biology: Structural Responses to Acidity Modification of Incoming dNTPs.; Biochemistry, 57:3934-3944, 2018; PubMed: 29874056; DOI: 10.1021/acs.biochem.8b00418

Experimental method

X-RAY DIFFRACTION (2.153 Å)